Study on Stroke during Sleep

Approximately 14 to 16 percent of stroke patients have their stroke during sleep according to Dr Chrristian Gerloff, Chairman of the Department of Neurology at the University Medical Center in Hamburg Germany.  In stroke it is very important to know when the symptoms occurred; if they happened 1 or 2 hours before waking up, then the patient can be treated with thrombolysis.  Stroke during sleep happens to approximately 60,000 patients in the US and 120,000 patients in Europe in a year.

In the case of strokes not older than 4.5 hours, a system was developed with about 80-90 % accuracy in measurement.  Specific MRI criteria were worked out with “diffusion-weighted image” to detect early changes after an acute ischemic stroke and FLAIR ( fluid attenuated inversion recovery ) image, both of whom would measure time of stroke.  If there is diffusion of a lesion but no changes in FLAIR then the stroke was triggered within the last 4 1/2 hours thus enabling treatment with thrombolysis IV.

Study coordinator Stefan Schwab, MD, chairman of the Department of Neurology University Clinic at the University of Erlangen-Nuremberg in Erlangen, Germany, told Medscape Medical News that based on calculations from pilot trials, the net benefit should …

WAKE UP is the trial to be conducted by Germany, Belgium, Denmark, England, France and Spain.  There will be forty centers allocated to this study.  The funding is totally independent of the pharmaceutical industry and is provided by the European Union.  The European Commission has committed 12 million Euros or $17.5 US dollars to this study and trial.

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